The Malawian was signed to the team in January last year and started playing for the club in July.
The Clever Boys as the team is popularly known, defeated Polokwane City 2 nil at Bidvest Stadium thanks to goals from James Keene and Daine Klate.
That, combined with Mamelodi Sundowns’ 2-2 draw at home to Maritzburg United, was enough to secure the title for Gavin Hunt’s team with a game to spare.
Mhango has scored nine goals in the ending season and is third on the top scorers’ list in the League.
The diminutive striker joined Wits at the start of the season from Bloemfontein Celtic.
He joins the likes of Enerst Mtawali and Patrick Mabedi to have won the South African Premier Soccer league medal.
Wits have become the seventh different championship winners in the PSL era, while Hunt has claimed a fourth title - adding to the three he won in 2007/08, 2008/09 and 2009/10 with SuperSport United.
Not only have Sundowns been dethroned, they are actually in danger of losing second place to Cape Town City, who are just a point behind the Brazilians after claiming a 1-0 win over Golden Arrows.